 |
Research Article
Assessment of vitamin D in erectile dysfunction patients with type 2 diabetes
1 Dermatology and Andrology Department, Suez Faculty of Medicine, Suez University, Suez 41552, Egypt
2 Dermatology, Andrology & STDs, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3 Radiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Address correspondence to:
Ahmed Bakr Elazab
Suez Faculty of Medicine, El-Zahra District, Suez 41552,
Egypt
Message to Corresponding Author
Article ID: 100006M05AE2026
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Bakr Elazab A, Hassan A, Ismail SRM, Mohamed El Adalany. Assessment of vitamin D in erectile dysfunction patients with type 2 diabetes. Edorium J Med 2026;5(1):1–9.ABSTRACT
Aims: Erectile dysfunction (ED) pathophysiology is a multifactorial condition that is primarily characterized by a vascular disorder that is related to a decrease in endothelial function. We aimed to assess the relation among erectile dysfunction (ED) and serum 25-hydroxyvitamin D (Vit D) levels in men with type 2 diabetes mellitus (T2DM).
Methods: This case–control study was directed on 20 male T2DM patients of at least 5 years’ duration, aged 20–60 years, and 20 age-matched healthy controls over a period of one year. All participants were obtained written informed consent before enrollment. All participants underwent full history taking, contain marital and sexual history (libido, frequency, morning erection, orgasm, ejaculation), smoking habits, demographic data, medical history, surgical history, and drug history (antihypertensives, lipid-lowering drugs, and prior ED treatment) A complete general and genital examination (penis, scrotum, testes, epididymis, and cord) was performed.
Results: A significant positive correlation was observed among serum Vit D levels and both erectile function (IIEF, p=0.007, r=0.584) and penile hemodynamic parameter PSV (p<0.001, r=0.848). On the contrary, Vit D was inversely correlated with CAIMT (p<0.001, r=−0.719), EDV (p=0.029, r=−0.536), and cavernous IMT (p<0.001, r=−0.904), indicating its protective vascular role. Regarding laboratory findings, Vit D displayed a significant negative correlation with HbA1c (p=0.013, r=−0.546). Utilizing ROC curve for recognition of best cut off point for Vit D in differentiating control groups and cases, 28.64 ng/mL was detected to have best specificity and sensitivity (65.0% and 70.0% separately). Total accuracy was observed to be 67.5%.
Conclusion: A significant correlation among erectile dysfunction and 25(OH)D deficit in T2DM men. This correlation may be because of 25(OH)D impact on endothelial dysfunction and glycemia.
Keywords: Erectile dysfunction, Penile and vascular ultrasound, Type 2 diabetes, Vitamin D
SUPPORTING INFORMATION
Author Contributions
Ahmed Bakr Elazab - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Hassan A - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Sherif Refaat M Ismail - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Mohamed El Adalany - Analysis of data, Interpretation of data, Drafting the article, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2026 Ahmed Bakr Elazab et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
